Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico.

ABSTRACT:

Background/aim

Heavy metals are known to induce oxidative stress and inflammation, and the association between metal exposure and adverse birth outcomes is well established. However, there lacks research on biomarker profiles linking metal exposures and adverse birth outcomes. Eicosanoids are lipid molecules that regulate inflammation in the body, and there is growing evidence that suggests associations between plasma eicosanoids and pregnancy outcomes. Eicosanoids may aid our understanding of etiologic birth pathways. Here, we assessed associations between maternal blood metal concentrations with eicosanoid profiles among 654 pregnant women in the Puerto Rico PROTECT birth cohort.

Methods

We measured concentrations of 11 metals in whole blood collected at median 18 and 26 w

SUBMITTER: Kim C 

PROVIDER: S-EPMC12912272 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature