Alcohol-seeking associations with resting state functional connectivity of the amygdala.

ABSTRACT:

Background

Prolonged alcohol use is associated with neuroadaptations that may contribute to continued alcohol consumption, even in the presence of adverse consequences. Although well studied in preclinical models, the neural mechanisms of aversion-resistant alcohol-seeking in humans are understudied.

Purpose

The goal of this study was to examine whether altered amygdala resting state functional connectivity (rsFC) is a mechanism for how lifetime drinking history and alcohol use disorder symptoms relate with objectively measured neutral and aversion-resistant alcohol-seeking in the human laboratory.

Methods

A sample of 55 adults (age 21-55, mean=32.18 years, 56.4 % female, 60.0 % White) completed two counterbalanced intravenous alcohol progressive-ratio self-administra

SUBMITTER: Dzemidzic M 

PROVIDER: S-EPMC12912274 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature