CD69 Regulates Gingival Inflammation and Microbiome in Periodontitis.

ABSTRACT: Dysbiotic subgingival biofilms initiate periodontitis, while the consequential destruction of periodontal tissues results from a dysregulated local immune response. Interstitial CD4⁺ T cells play a crucial role in orchestrating periodontal inflammation. Upon activation, CD4⁺ T cells express CD69 receptors, which can influence their migration patterns, phenotype, and function during inflammation. Here, we report that in the absence of CD69, memory CD4⁺ T cells (mCD4⁺ T cells) derived from gingival and cervical lymph nodes (cLNs) display an increased proinflammatory phenotype. Following in vitro activation, negative-selected mCD4⁺ T cells from cLNs of CD69^KO mice showed enhanced expression of interleukin (IL)-17A (P = 0

SUBMITTER: Saavedra FM 

PROVIDER: S-EPMC12912275 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature