Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis.

ABSTRACT:

Objectives

Hyperinflammatory and hypoinflammatory molecular subphenotypes in sepsis and acute respiratory distress syndrome have divergent mortality and treatment responses in secondary analyses of randomized controlled trials. However, the prevalence of immunocompromise is low in these populations, and how preexisting immunocompromise contributes to subphenotypes is unknown. We studied two observational sepsis cohorts to test associations between immunocompromise and the hyperinflammatory subphenotype and to assess whether the prognostic relevance of molecular subphenotypes is generalizable to immunocompromised populations.

Design

Observational cohort study.

Setting

Prospective data from two ICU cohorts in the United States.

Patients

We included 1826 patients

SUBMITTER: Weingart MF 

PROVIDER: S-EPMC12912362 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature