Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.

ABSTRACT:

Rationale

Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing the use of stem cell therapies, consensus on the optimal stem cell type is not adequately defined. The modest cardiac repair and functional improvement in patients with cardiac disease warrants identification of a novel stem cell population that possesses properties that induce a more substantial improvement in patients with heart failure.

Objective

To characterize and compare surface marker expression, proliferation, survival, migration, and differentiation capacity of cortical bone stem cells (CBSCs) relative to mesenchymal stem cells (MSCs) and cardiac-derived stem cells (CDCs), which have already been tested in earl

SUBMITTER: Mohsin S 

PROVIDER: S-EPMC12912447 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature