Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.

ABSTRACT:

Background

Previously, we have shown that radiofrequency (RF) renal denervation (RDN) reduces myocardial infarct size in a rat model of acute myocardial infarction (MI) and improves left ventricular (LV) function and vascular reactivity in the setting of heart failure following MI.

Objectives

The authors investigated the therapeutic efficacy of RF-RDN in a clinically relevant normotensive swine model of heart failure with reduced ejection fraction (HFrEF).

Methods

Yucatan miniswine underwent 75 min of left anterior descending coronary artery balloon occlusion to induce MI followed by reperfusion (R) for 18 weeks. Cardiac function was assessed pre- and post-MI/R by transthoracic echocardiography and every 3 weeks for 18 weeks. HFrEF was classified by an LV ejection fra

SUBMITTER: Sharp TE 

PROVIDER: S-EPMC12912457 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature