The JAK1-STAT1 signaling pathway triggers inflammation responses in chronic obstructive sleep apnea rat model.

ABSTRACT:

Background

Chronic obstructive sleep apnea (OSA) drives systemic inflammation; the role of the JAK1-STAT1 pathway is unclear.

Objective

To elucidate JAK1-STAT1 involvement in OSA-related inflammation using a chronic intermittent hypoxia (CIH) model.

Methods

Sprague-Dawley rats underwent 8-week CIH (FiO₂ cycling 5-21%, 8h/day) or normoxia (Sham). Serum cytokines (ELISA) and lung p-JAK1/p-STAT1 (Western blot/IHC) were analyzed. A CIH subset received JAK1 inhibitor filgotinib. Airway resistance was assessed via forced oscillation.

Results

CIH elevated serum IL-6/TNF-α versus Sham (p < 0.05) and increased lung p-JAK1/p-STAT1. Filgotinib reduced cytokines, suppressed p-JAK1/p-STAT1, attenuated leukocyte infiltration/collagen deposition, and improved airway resistanc

SUBMITTER: Yang L 

PROVIDER: S-EPMC12912577 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature