The immunopathological crosstalk of diabetic periodontitis: Single-cell insights into monocyte dysregulation.

ABSTRACT: Periodontitis (PD) and type 2 diabetes mellitus (DM) are bidirectionally associated through shared chronic inflammatory mechanisms. Although monocytes serve as central immune mediators in both pathologies, their functional heterogeneity and dynamic alterations in diabetic periodontitis (PDDM) remain poorly characterized. Utilizing single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) from healthy controls, PD patients, and PDDM subjects, we systematically investigated the immunopathological crosstalk between these comorbidities. Our analysis revealed a significant shift in monocyte subpopulations, with PDDM patients exhibiting increased classical monocytes (CD14++CD16-) and decreased nonclassical monocytes (CD14 + CD16++) compared to PD counterparts. Function

SUBMITTER: Si C 

PROVIDER: S-EPMC12912578 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature