Identification of SORCS1 as a candidate gene associated with canine behavioral traits: Insights from guide dog training outcomes.

ABSTRACT: Although genetic factors contribute to behavioral variation in working dogs, the underlying molecular determinants remain poorly understood. The sortilin-related VPS10 domain-containing receptor 1 (SORCS1) gene is highly expressed in the central nervous system and has been implicated in neuronal signaling and synaptic regulation. A preliminary genome-wide association study suggested an association between SORCS1 variants and guide dog training outcomes. However, this result relied on only 28 dogs and lacked sufficient statistical power. In this study, we expanded the sample size and evaluated the association between SORCS1 polymorphisms and behavioral suitability in 160 dogs, using pass/fail training outcomes as behavioral trait indicators. We initially validated 12 candidate SNPs within S

SUBMITTER: Omi T 

PROVIDER: S-EPMC12912605 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature