Characterization of temporal protein production in Pseudomonas aeruginosa biofilms.

ABSTRACT: Phenotypic and genetic evidence supporting the notion of biofilm formation as a developmental process is growing. In the present work, we provide additional support for this hypothesis by identifying the onset of accumulation of biofilm-stage specific proteins during Pseudomonas aeruginosa biofilm maturation and by tracking the abundance of these proteins in planktonic and three biofilm developmental stages. The onset of protein production was found to correlate with the progression of biofilms in developmental stages. Protein identification revealed that proteins with similar function grouped within similar protein abundance patterns. Metabolic and housekeeping proteins were found to group within a pattern separate from virulence, antibiotic resistance, and quorum-sensing-related proteins

SUBMITTER: Southey-Pillig CJ 

PROVIDER: S-EPMC1291272 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature