Linking spinal circuit reorganization to recovery after thoracic spinal cord injury.

ABSTRACT: Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely result from and give insight into the reorganization within spared and injured spinal circuitry. Previously, we developed computational models of the mouse spinal locomotor circuitry controlling speed-dependent gait expression (Danner et al., 2017; Zhang et al., 2022). Here, we adapted these models to the rat and used the adapted model to explore potential circuit-level changes underlying altered gait expression observed after recovery from two different thoracic spinal cord injuries (lateral hemisection and contusion) that have roughly comparable levels of locomotor recovery (Danner et al., 202

SUBMITTER: Shevtsova NA 

PROVIDER: S-EPMC12912727 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature