Prognostic value of serum bilirubin in southern Chinese patients with advanced nasopharyngeal carcinoma.

ABSTRACT:

Background

We evaluated the prognostic value of serum bilirubin in advanced nasopharyngeal carcinoma (NPC) patients.

Methods

Seven-hundred fifty-nine advanced NPC patients treated with definitive chemoradiotherapy were retrospectively analyzed. Serum indirect bilirubin (IBIL) and direct bilirubin (DBIL) were measured before treatment. To evaluate different cutoff points for serum bilirubin, we utilized ROC curves. The Kaplan-Meier method and log-rank test were adopted to calculate and compare survival outcomes. Cox proportional hazard models were used to perform univariate and multivariate analyses.

Results

At 5 y, IBIL >7.15 μmol/l were significantly associated with superior progression-free survival (PFS, 83.6% vs 70.3%; P < .001), overall survival (OS, 88.6% vs 80.

SUBMITTER: Yao JJ 

PROVIDER: S-EPMC12912730 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature