Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model.

ABSTRACT: Age-related erectile dysfunction (ARED) represents a significant clinical challenge due to the interplay between chronic comorbidities and age-related physiological decline. This study investigated the therapeutic potential of near-infrared photobiomodulation therapy (NIR-PBMT) in ARED mice, focusing on molecular and physiological mechanisms of complex erectile function restoration. Aged mice received NIR-PBMT (4 J cm -2 ) every 48 h for 2 weeks. Erectile function was evaluated using the maximum intracavernosal pressure/mean arterial pressure (ICP max /MAP) ratio following cavernous nerve stimulation. Histological analysis and western blotting revealed significant improvements in penile tissue architecture, including increased smooth muscle content, reduced collagen deposition, and altered

SUBMITTER: Zheng ZJ 

PROVIDER: S-EPMC12912745 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature