Purified diet reduces intestinal IgA and alters the microbiota accordingly.

ABSTRACT: Diet can affect health directly or by altering the gut microbiota; thus, there are strong interrelationships between the gut immune system, gut microbiota and diet. This study examined the effects of ingesting AIN-93M purified diet (PD) on gut immune function and gut microbiota in DO11·10 mice, in which T cell-dependent and T cell-independent (TI) IgA can be analysed separately. Ingestion of the PD for 2 weeks reduced both T cell-dependent and TI secretory IgA in the faeces compared with non-PD, whereas the diet did not affect T cell-dependent and TI serum IgA. Ingestion of the PD had no effect on systemic immune system splenocyte responses. Ingestion of the PD reduced intestinal tissue expression levels of B-cell activating factor and A proliferation-inducing ligand, cytokines involved in

SUBMITTER: Goto M 

PROVIDER: S-EPMC12912838 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature