Cognitive and clinical profiles in first-episode psychosis and their relationship with functional outcomes.

ABSTRACT:

Background

While cognitive impairment is a core feature of psychosis, significant heterogeneity in cognitive and clinical outcomes is observed.

Aims

The aim of this study was to identify cognitive and clinical subgroups in first-episode psychosis (FEP) and determine if these profiles were linked to functional outcomes over time.

Method

A total of 323 individuals with FEP were included. Two-step hierarchical and k-means cluster analyses were performed using baseline cognitive and clinical variables. General linear mixed models were used to investigate whether baseline cognitive and clinical clusters were associated with functioning at follow-up time points (6-9, 12 and 15 months).

Results

Three distinct cognitive clusters were identified: a cognitively in

SUBMITTER: Cowman M 

PROVIDER: S-EPMC12912872 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature