Single-Cell Transcriptomic Analysis of Macaque LGN Neurons Reveals Novel Subpopulations.

ABSTRACT: Neurons in the lateral geniculate nucleus (LGN) provide a pivotal role in the visual system by modulating and relaying signals from the retina to the visual cortex. Although the primate LGN, with its distinct divisions (magnocellular, M; parvocellular, P; and koniocellular, K), has been extensively characterized, the intrinsic heterogeneity of LGN neurons has remained unexplained. With the development of high-throughput single-cell transcriptomics, researchers can rapidly isolate and profile large sets of neuronal nuclei, revealing a surprising diversity of genetic expression within the nervous system, such as two types of K neurons (as reported by Bakken et al., eLife, 10, e64875, 2021). Here, we analyzed the transcriptomes of individual cells belonging to macaque LGN using raw data from

SUBMITTER: Sun SH 

PROVIDER: S-EPMC12913271 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature