In Humans, fMRI Reveals That Striosome-Like and Matrix-Like Striatal Voxels Are Engaged in Different Phases of Movement.

ABSTRACT: The striatum is organized into two neurochemically and anatomically distinct compartments, the striosome and matrix, that play specialized roles in motor and cognitive functions. While extensive animal research has elucidated compartment-specific contributions to reward, learning and motor control, direct evidence for compartment specialization in humans is lacking. We defined human striatal voxels as striosome-like or matrix-like based on biases in structural (diffusion) connectivity. Then we investigated functional activation patterns in those compartment-like voxels using task-based functional MRI (tfMRI) during pre-movement cue and five motor conditions (left/right hand, left/right foot, and tongue movements). Functional activation was strikingly segregated: striosome-like voxels were

SUBMITTER: Sadiq A 

PROVIDER: S-EPMC12913692 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature