The Impact of Estrogen on Stromal Elements in the Proximal Airway in Idiopathic Subglottic Stenosis.

ABSTRACT:

Objectives

Idiopathic subglottic stenosis (iSGS) is an unexplained fibrosis of the proximal airway that predominantly impacts Caucasian women. Clinically, premenopausal patients suffer from higher recurrence rates, potentially implicating ovarian hormone 17B-estradiol (E2) in disease pathogenesis. Despite its relationship with disease phenotype and severity, the mechanistic role of E2 in subglottic fibrosis has not been investigated.

Methods

Primary human cell lines derived from the airway scar of iSGS patients were utilized for in vitro study to assess the impact of E2 on proximal airway cells (fibroblasts, epithelial cells, and endothelial cells). Alterations in RNA and extracellular matrix protein expression were assessed in fibroblasts (n = 5 primary cell lines) followin

SUBMITTER: Mace EL 

PROVIDER: S-EPMC12913749 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature