Dataset Information
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling.
Ontology highlight
ABSTRACT:
SUBMITTER: Choi SH
PROVIDER: S-EPMC12913832 | biostudies-literature | 2026 Feb
REPOSITORIES: biostudies-literature
Publications
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling.
Cellular and molecular life sciences : CMLS 20260213 1
The COP9 signalosome (CSN) regulates Cullin–RING E3 ligases (CRLs) through deneddylation and complex stabilization. However, the specific molecular functions of individual CSN subunits remain unclear. In this study, we identified CSN4 as a critical regulator of DDB1 stability and CRL4 function during the cellular response to DNA damage. CSN4 binds directly to DDB1, and its loss leads to the destabilization of DDB1, reduced CRL4 assembly, and impaired DNA damage-induced ubiquitination. The DDB1 K ...[more]