Clonal determinants of organotropism and survival in metastatic uveal melanoma.

ABSTRACT: Uveal melanoma (UM), the most common intraocular cancer in adults, metastasizes to the liver in 90% of cases. Integrating DNA sequencing of 144 metastases with decade-long patient outcomes, we found that liver metastases are more enriched for BAP1-mutant, monosomy 3 clones, compared to extrahepatic metastases. BAP1 loss in liver metastases independently predicts poorer post-metastatic survival. Patterns of dissemination are set early in primary tumors, enabling molecular profiling to forecast metastatic spread.

SUBMITTER: Jones BSCL 

PROVIDER: S-EPMC12913882 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature