Predictors of reverse cardiac remodeling after sacubitril/valsartan in heart failure with reduced ejection fraction.

ABSTRACT: Sacubitril/valsartan (Sac/Val) is associated with reverse cardiac remodeling in heart failure with reduced ejection fraction (HFrEF). However, the predictors of reverse cardiac remodeling after Sac/Val have not yet been fully established. We aimed to evaluate the predictors of reverse cardiac remodeling in patients with HFrEF, with a focus on HF duration and the dose of Sac/Val. In this retrospective, multicenter cohort study, 600 patients with HFrEF who received a Sac/Val prescription were enrolled at six tertiary hospitals in Korea between February 2017 and April 2019. After excluding patients without baseline or 12-month follow-up echocardiographic data, 294 patients were enrolled. Reverse cardiac remodeling was defined by comparing the baseline and follow-up echocardiographic data: an

SUBMITTER: Yoon M 

PROVIDER: S-EPMC12913927 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature