Multi-omic analysis of human PHACTR1 signaling networks.

ABSTRACT: Genetic studies have linked PHACTR1 to a range of vascular diseases, underscoring its pivotal role in vascular biology. However, the full spectrum of PHACTR1-mediated signaling pathways remains largely unexplored. To bridge this gap, we employ a multi-omics pipeline combining pairwise differential expression analysis, multi-omics pathway integration, and feature-level correlation analyses across four distinct omics datasets to map the global signaling networks driven by PHACTR1. By integrating transcriptomic, proteomic, metabolic, and lipidomic profiles from human HT1080 cells with PHACTR1 overexpression or knockdown, and then validating key findings in primary human endothelial cells, here we show that PHACTR1 exerts broad control over fundamental cellular processes beyond cytoskeletal re

SUBMITTER: Wolhuter K 

PROVIDER: S-EPMC12913993 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature