Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies.

ABSTRACT: Microgravity strongly affects human physiology during spaceflight. Biological sex has not yet been sufficiently considered as a variable for spaceflight deconditioning. The VivalDI studies investigated physiological systems affected by 5-days dry immersion (DI) in females and males, with a focus on immune changes in this report. In both sexes proportions of peripheral granulocytes and NK cells were elevated during DI and T-cell numbers were reduced. Leukocyte activation and cytokine levels were moderately affected. Females showed a higher Torque-Teno-virus shedding at the end of DI. Noradrenaline concentrations increased during the study with sex-specific patterns. Hemodynamics suggest that immunological changes were caused by DI-induced fluid shifts. Moreover, male study participants' pat

SUBMITTER: Moser D 

PROVIDER: S-EPMC12914047 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature