Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

ABSTRACT:

SUBMITTER: Borbinha J

PROVIDER: S-EPMC12914293 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

Project description:Tissue regeneration relies on precise molecular mechanisms controlling cell fate transitions, with cell metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an important epigenetic modification involved in the regulation of gene expression across various biological processes. In this study, we report an increase in global histone lactylation and H3K18Lac levels in the mesenchyme and osteoblasts of the zebrafish caudal fin, during the early stages of regeneration. Our findings demonstrate that this epigenetic modification is functionally regulated by increased lactate levels, while inhibition of glycolysis and lactate production significantly reduces histone lactylation. These results suggest that metabolic reprogramming, in response to caudal fin injury, regulates histone lactylation, potentially modulating gene expression essential for cell plasticity and proliferation. This study expands our understanding of how metabolic-epigenetic interactions influence regenerative processes, providing valuable insights for the development of novel therapeutic strategies to enhance tissue repair.

2026-01-19 | GSE311919 | GEO

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

Project description:Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

| PRJNA1371935 | ENA

Proteomic analysis of zebrafish caudal fin regeneration.

Project description: Not available

| S-EPMC3433902 | biostudies-literature

Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration.

Project description: Not available

| S-EPMC9429828 | biostudies-literature

Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration.

Project description: Not available

| S-EPMC5559610 | biostudies-literature

Autophagy is required for zebrafish caudal fin regeneration.

Project description: Not available

| S-EPMC3950318 | biostudies-literature

Phosphoproteomic association in zebrafish caudal fin regeneration.

Project description:The study mapped the global phosphorylation modifications within regenerating tissue of zebrafish caudal fins.

2024-12-02 | PXD050706 | Pride

Distribution and Restoration of Serotonin-Immunoreactive Paraneuronal Cells During Caudal Fin Regeneration in Zebrafish.

Project description: Not available

| S-EPMC6763699 | biostudies-literature

Effect of Small Molecules in Zebrafish Caudal Fin Regeneration

Project description:The study analysed proteomic changes during zebrafish caudal fin tissue regeneration post small molecule treatment.

2025-11-24 | PXD060144 | Pride

Small RNA and mRNA expression profiling during zebrafish caudal fin regeneration

Project description:Previous studies of zebrafish caudal fin regeneration have shown that multiple genetic programs are moduled through regulatory factors. MicroRNAs are short highly conserved non-coding genes that suppress expression of target genes and thereby control multiple genetic programs. Given their important regulatory roles and evolutionary conservation, we hypothesize that microRNAs define a conserved genetic regulatory circuit important for appendage regeneration. We characterized microRNA expression during zebrafish caudal fin regeneration using small RNA sequencing. The stages of caudal fin regeneration were assayed for mRNA expression using mRNA sequencing. Small RNA and mRNA gene expression profiling during 0 and 4 days post amputation.

2016-06-01 | E-GEOD-74415 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data