3D-Printed Microneedle Patch for the Treatment of Melanoma via Synergistic Chemotherapy and Photothermal Therapy.

ABSTRACT: Melanoma is a malignant type of skin cancer that originates from pigment-producing cells called melanocytes. Alongside its aggressive trajectory, it is characterized by metastasis. The lack of targeting ability and high toxicity in traditional chemotherapy, along with issues such as the dermal barrier and patient compliance, necessitate local and synergistic treatment approaches. Patches that are part of transdermal drug delivery systems and use hydrogel microneedles to deliver drugs noninvasively, locally, and synergistically, are a recently emerging treatment alternative. In this study, we designed a microneedle patch composed of microneedles produced by 3D digital light processing, which were made of sodium alginate and GelMA. The GelMA support base contained an anticancer drug (5-FU) a

SUBMITTER: Yilmaz H 

PROVIDER: S-EPMC12914633 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature