Maternal bioactive lipids during pregnancy and early childhood neurodevelopment and behavior.

ABSTRACT:

Background

Maternal immune activation, including inflammation and oxidative stress during pregnancy, has been linked to child neurodevelopmental problems (NDP) and emotional and behavioral problems (EBP). Polyunsaturated fatty acids (PUFAs) and their oxidized metabolites (oxylipins) are important bioactive lipids that modulate immune responses, inflammation, and oxidative stress. However, their roles in child NDP and EBP remain unclear.

Methods

This study included 259 mother-child pairs from the PROTECT birth cohort in Puerto Rico. Maternal plasma samples collected around 26 weeks' gestation were analyzed for bioactive lipid levels using high-performance liquid chromatography-tandem mass spectrometry. Child NDP and EBP were assessed at ages 1-3 using the Battelle Development

SUBMITTER: Park S 

PROVIDER: S-EPMC12914742 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature