Dataset Information
The causal association between systolic blood pressure and breast cancer: a two sample Mendelian randomization study.
Ontology highlight
ABSTRACT:
SUBMITTER: Awada Z
PROVIDER: S-EPMC12914972 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
The causal association between systolic blood pressure and breast cancer: a two sample Mendelian randomization study.
BMC cancer 20260122 1
BACKGROUND: Breast cancer (BC) is the leading cause of cancer incidence worldwide. Observational studies have suggested that hypertension may be a risk factor for BC. We tested whether systolic blood pressure (SBP) may influence BC and BC subtypes using a Mendelian randomisation (MR) approach. METHODS: We used 334 genetic variants associated with SBP as an instrumental variable. Effect estimates were obtained from the UK biobank (n = 469,767; SNP-exposure estimates) and the Breast Cancer Associa ...[more]