A Time-Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full-Thickness Regeneration in Diabetic Wounds.

ABSTRACT: Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments, posing significant clinical challenges. Current dressings predominantly focus on monofunctional interventions, failing to resolve the "inflammation-repair imbalance". In this study, we propose a chronotherapeutic bilayer system designed for stage specific regulation. The lower GelMA cryogel loaded with polyphenols acts as a "cleaner", removing AGEs via hydrogen bond capture and pore entrapment and activating the PPARγ pathway to remodel the anti-inflammatory microenvironment; The upper polycaprolactone nanofibers directionally deliver PDGF-BB, enabling sustained release to activate fibroblast migration an

SUBMITTER: Yi L 

PROVIDER: S-EPMC12915078 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature