A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation.

ABSTRACT: Craniofacial bone defects remain a significant clinical challenge due to the complex healing process among immune regulation, vascularization, and osteogenesis. Asiatic acid (AA), a natural pentacyclic triterpenoid, has shown promise in modulating inflammation and promoting bone repair, yet its clinical application is hampered by poor solubility, low bioavailability, and lack of targeted delivery. Here, a multifunctional hydrogel-integrated DNA nanostructure system is reported, in which AA-loaded DNA tetrahedra are embedded within a Hyaluronic Acid Methacrylate (HAMA) hydrogel（HM-TDN@AA） to enhance local retention, bioavailability, and controlled release. The HM-TDN@AA system significantly inhibited osteoclastogenesis and enhanced the osteogenic and angiogenic activity of mesenchymal stem

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12915104 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature