A Universal Metal-Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration.

ABSTRACT: Under metabolic disorders such as diabetes, the regenerative capacity of bone tissue is compromised, characterized by hyperglycemia-induced oxidative stress, impaired osteogenesis, and dysregulated angiogenesis. These complications undermine the efficacy of conventional bone repair materials, limiting their capacity to promote effective healing. Herein, we developed a metal-flavonoid functionalized coating strategy that integrates osteogenic and angiogenic metal ions with natural antioxidant flavonoids. Leveraging their chelation ability and strong surface affinity, a one-pot approach is established to endow conventional bone repair materials with tailored biofunctions that modulate the diabetic bone microenvironment and facilitate regeneration. Among the tested candidates, copper-querceti

SUBMITTER: Yang C 

PROVIDER: S-EPMC12915126 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature