Biocatalytic Nanoregulators Restore Joint Redox-Immune Homeostasis in Rheumatoid Arthritis.

ABSTRACT: Rheumatoid arthritis (RA), a debilitating autoimmune disorder marked by progressive synovitis and osteochondral erosion, presents critical therapeutic challenges due to the limitations of existing regimens, including non-specific biodistribution and compromised risk-benefit profiles. In this study, a novel therapeutic approach is proposed utilizing mesenchymal stem cell-derived extracellular vesicles (EVs) coating on ruthenium-loaded metal-organic frameworks (Ru@ZrMOF), which exhibit catalase mimetic activities. The EVs coating enhances the biocompatibility and targeting efficiency of the Ru@ZrMOF, while also promoting cartilage protection. Through reactive oxygen species (ROS) scavenging and oxygen production, Ru@ZrMOF/EVs significantly alleviate joint inflammation, promote cartilage prot

SUBMITTER: Wang X 

PROVIDER: S-EPMC12915140 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature