Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide.

ABSTRACT:

Background

Safe sensory-selective local anesthetics would be a major advance in the management of acute and chronic pain. This articles describes the sensory-selective local anesthetic properties and the toxicity profile of a known metabolite of amino-amide local anesthetics, 2',6'-pipecoloxylidide (PPX).

Methods

PPX was synthesized and made into its hydrochloride salt. PPX or ropivacaine (ROP) were injected at the sciatic nerve or intrathecally in rats, who then underwent modified hotplate (sensory) testing and weight-bearing (motor) testing. Rats injected with PPX or ROP were assessed for clinical toxicity endpoints. Conduction blockade was studied with single-unit recordings in mice. Biocompatibility was assessed histologically.

Results

In male rats, sciatic sensor

SUBMITTER: Ostertag-Hill CA 

PROVIDER: S-EPMC12915269 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature