Variability of menstrual cycles by age, polycystic ovary syndrome, and early-life cycle irregularity in the apple Women's Health Study.

ABSTRACT:

Background

Polycystic ovary syndrome is a common endocrine disorder, characterized by oligomenorrhea and androgen excess. Only a few studies have addressed the natural history of menstrual cycles among women with polycystic ovary syndrome and/or irregular cycles, most with limited sample size and homogenous populations.

Objective

We describe age-related differences in menstrual cycle length and regularity for those with and without a diagnosis of polycystic ovary syndrome.

Study design

We included participants in the Apple Women's Health Study, a digital US cohort, who consented and enrolled between November 2019 and March 2024 and provided menstrual logging data (on days of menstrual bleeding) for at least 3 cycles without hormone use, pregnancy, or lactation. We eva

SUBMITTER: Mortimer R 

PROVIDER: S-EPMC12915291 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature