Pilot-scale fermentation to produce trichodiene, a fungal volatile that suppresses trichothecene production in mycotoxigenic fungi.

ABSTRACT: Trichodiene is a sesquiterpene hydrocarbon and the precursor of trichothecene mycotoxins produced by Fusarium and other fungi. Interestingly, utilizing trichodiene as a volatile treatment has been shown to reduce mycotoxin production in Fusarium graminearum-infected wheat heads. This research developed a pilot-scale fungal fermentation method to produce trichodiene as a biofumigant to mitigate mycotoxin contamination. A TRI4 mutant strain of Fusarium sporotrichioides was used to mass-produce trichodiene. Xanthotoxin, a furanocoumarin produced by parsnips, was used to enhance trichodiene production in this mutant. Xanthotoxin treatments significantly increased trichodiene yield and were found to promote lipid droplet release from the fungal germlings. Benchtop sc

SUBMITTER: Hay WT 

PROVIDER: S-EPMC12915363 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature