Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection.

ABSTRACT:

Background

Spontaneous coronary artery dissection (SCAD) is an uncommon cause of myocardial infarction that disproportionately affects women, particularly during pregnancy and the peripartum period. Limited understanding of its underlying pathophysiology hinders the development of effective preventive and therapeutic strategies.

Methods

This study investigated associations between genetically predicted circulating proteins and tissue-specific RNA levels with genetically predicted SCAD risk using Mendelian randomization and Bayesian colocalization. Genetic scores for >1500 circulating proteins were derived from the UK Biobank (N=34 557) and deCODE (N=35 559). Scores for 13 848 gene transcripts in arterial and fibroblast tissues were generated from Genotype-Tissue Expression d

SUBMITTER: Ardissino M 

PROVIDER: S-EPMC12915550 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature