Reproducibility and Reliability of Free-Water-Corrected Diffusion Tensor Imaging of the Brain: Revisited.

ABSTRACT: Diffusion tensor imaging (DTI) corrected for the free-water (FW) enables the separation of a hindered Gaussian-like profile from an isotropic component, which represents diffusion found in cerebrospinal and interstitial fluids within the extracellular space of grey and white matter. The assessment of the reproducibility and reliability properties of FW-corrected DTI is a crucial factor in demonstrating the potential clinical utility of this refinement, particularly considering the examinations across multiple medical centres. This paper explores the variability, reliability, and separability properties of free-water volume fraction (FWVF) and FW-corrected DTI-based measures in healthy human brain white matter using publicly available test-retest databases acquired in (1) intra-scanner, (2)

SUBMITTER: Pieciak T 

PROVIDER: S-EPMC12915591 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature