Turbulence drives arteriovenous remodeling: an experimentally validated multi-scale model of neointimal hyperplasia.

ABSTRACT: Objectives.Arteriovenous fistula (AVF) failure is a frequent clinical problem among end stage renal patients seeking durable long term dialysis access. The most common histologicalin vivoobservation of AVF failure is endothelial injury at the juxta-anastomosis area (JAA) followed by thrombus deposition and subsequent neointimal hyperplasia (NH). While hemodynamic factors have been postulated to affect AVF remodeling and failure, the spatial correlations between changes in hemodynamics post AVF creation andin vivophysiologic observations remain poorly understood. In this work, we developed a novel computational fluid dynamics (CFDs) model of an AVF using a pre-established aortocaval mouse model and integrated it with agent-based modeling (ABM) for NH.Approach.The

SUBMITTER: Varsanik MA 

PROVIDER: S-EPMC12915627 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature