A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity in <i>Caenorhabditis elegans</i>.

ABSTRACT: Lateralization of neuronal functions plays a critical role in regulating behavioral flexibility, but the underlying molecular mechanisms are challenging to establish at a single-neuron level. We previously showed that attraction of Caenorhabditis elegans to a medium-chain alcohol switches to avoidance in a uniform background of a second attractive odorant. This context-dependent behavioral plasticity is mediated by symmetric inversion of the odor-evoked response sign in the bilateral AWC olfactory neurons. Here, we show that this symmetric response plasticity is driven by asymmetric molecular mechanisms in the AWC neuron pair. Mutations in the gcy-12 receptor guanylyl cyclase abolish odor response plasticity only in AWC^OFF; the opposite odor-evoked response signs i

SUBMITTER: Pandey A 

PROVIDER: S-EPMC12915687 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature