Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation.

ABSTRACT: Peste des petits ruminants (PPR) is a WOAH notifiable disease affecting sheep and goats, caused by Peste des petits ruminants virus (PPRV), a morbillivirus of the Paramyxoviridae family. Infection with PPRV leads to immunosuppression, creating conditions for opportunistic infections that can result in animal mortality. Although goats generally exhibit more severe clinical signs than sheep, the underlying mechanisms driving this species-specific difference remain poorly understood. Dendritic cells (DC), which play a pivotal role in initiating immune responses, are among the immune targets of PPRV in small ruminants. In this study, we examined the impact of PPRV on caprine immune cells, focusing on CD14⁺ monocytes and monocyte-derived dendritic cells (MoDC). Our findings in

SUBMITTER: Nogales-Altozano P 

PROVIDER: S-EPMC12915780 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature