Spontaneous Mutations Occur More in Highly Transcribed Regions in Daphnia.

ABSTRACT: Many molecular processes (eg replication, recombination, and transcription) use DNA as a template molecule, which may lead to an increase or decrease in the likelihood of spontaneous mutation and/or repair of mutations to this key information storage molecule. In the case of transcription, both positive and negative correlations with the likelihood of mutation have been observed across species, which have formed the basis of two proposed mechanistic models: transcription-associated mutagenesis and transcription-coupled repair. Here, we examine the patterns of spontaneous mutations in regions of low and high transcription in two species of the aquatic microcrustacean, Daphnia. By mapping events from a long-term mutation accumulation study (n = 66 lineages derived from nine different genotyp

SUBMITTER: Coate JE 

PROVIDER: S-EPMC12915781 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature