Soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy.

ABSTRACT:

Aims

Continuous positive airway pressure (CPAP) is an established therapy for obstructive sleep apnea (OSA), but how CPAP compliance changes inflammation/cytokine activation remains unclear.

Materials and methods

Plasma from patients with OSA (n = 50) and control subjects (n = 6) were subjected to soluble cytokine receptor profiles - an index of cytokine activation.

Results

With OSA, plasma levels of sCD30, sEGFR, sIL1RII, and sVEGFR2 increased by over 2-fold (p < 0.05). In CPAP-compliant patients (n = 22), Plasma levels of sCD30, sEGFR, sIL1RI, sIL1RII, sIL2Ra, sVEGFR1, and sVEGFR2 decreased in CPAP compliant patients (n = 22) after 90 d of CPAP, whereas in CPAP non-compliant patients (n = 28), these soluble cytokine profiles

SUBMITTER: Kiriluk SH 

PROVIDER: S-EPMC12915782 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature