Intracellular Localization of DNA-Wrapped Single-Walled Carbon Nanotube Sensors for Nitric Oxide Detection in Triple-Negative Breast Cancer Cells.

ABSTRACT: Spatiotemporal sensors capable of monitoring analyte activity in subcellular compartments of cells are critical to advancing our understanding of complex disease progression. Nitric oxide (NO) plays a key role in tumor progression, yet its precise function remains unclear due to its bimodal effect, which is influenced by its subcellular distribution. Factors such as membrane permeability, NO reactivity, and redox states of intracellular compartments may determine whether NO promotes or suppresses tumor growth. Current sensors are limited in providing spatial and temporal information about NO in live cells. Single-walled carbon nanotubes (SWNT), specifically (6,5) SWNT functionalized with (AT)₁₅ DNA, have demonstrated potential for intracellular NO detection, but their organelle-

SUBMITTER: Plange PNA 

PROVIDER: S-EPMC12915888 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature