In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.

ABSTRACT: In Parkinson's disease (PD), the beta band (12-30 Hz) component of basal ganglia activity is pathologically high. Deep brain stimulation (DBS) is an effective treatment to suppress symptoms of PD and is known to suppress pathological beta activity. However, the mechanism underlying this effect is not completely understood. Here, we tested the circuital effects of DBS in a computational model of the basal ganglia network in dopamine-depleted condition mimicking PD. Our model reproduces suppression of beta pathological oscillations in the basal ganglia network induced by subthalamic nucleus (STN) DBS. Crucially, this occurs for realistic levels of DBS intensity only if we incorporate short-term plasticity in projections from STN, increasing the DBS intensity required for suppression of patho

SUBMITTER: Ahmadipour M 

PROVIDER: S-EPMC12916059 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature