Cell cycle-dependent cues regulate temporal patterning of the <i>Drosophila</i> central brain neural stem cells.

ABSTRACT: During nervous system development, diverse types of neurons and glia are sequentially generated by self-renewing neural stem cells (NSCs). Temporal changes in gene expression within NSCs are thought to regulate neural diversity; however, the mechanisms regulating the timing of these temporal gene transitions remain poorly understood. Drosophila type 2 NSCs, like human outer radial glia, divide to self-renew and generate intermediate neural progenitors, amplifying and diversifying the population of neurons innervating the central complex, a brain region crucial for sensorimotor coordination. Type 2 NSCs express over a dozen genes temporally, broadly classified as early- and late-expressed genes. A conserved gene, seven-up, mediates early-to-late gene expression by activating e

SUBMITTER: Morales Chaya GN 

PROVIDER: S-EPMC12916099 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature