Emotion Processing in Schizophrenia: Insights From a Brain Imaging Study Comparing Patients, Siblings, and Healthy Controls.

ABSTRACT: Abnormal facial emotion recognition has been proposed as a potential endophenotype for schizophrenia, as both patients with schizophrenia and their healthy relatives show difficulties in recognizing negative facial emotions. In psychiatric disorders, brain functioning is considered highly informative for endophenotype research. However, recent studies have raised questions about our current understanding of the neural correlates of emotion recognition across the schizophrenia spectrum, pointing out two major limitations in previous research. First, individual fMRI studies and meta-analyses have predominantly used neutral stimuli as a comparator in emotional tasks. Yet, recent evidence indicates that neutral stimuli are not perceived as truly neutral by patients with schizophrenia or their

SUBMITTER: Fiorito AM 

PROVIDER: S-EPMC12916247 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature