Retinal calcium waves coordinate uniform tissue patterning of the <i>Drosophila</i> eye.

ABSTRACT: Optimal neural processing relies on precise tissue patterning across diverse cell types. Here, we show that spontaneous calcium waves arise among non-neuronal support cells in the developing Drosophila eye to drive retinal morphogenesis. These waves are initiated by Cad96Ca receptor tyrosine kinase signaling, triggering phospholipase C-γ-mediated calcium release from the endoplasmic reticulum. A cell type-specific "innexin code" coordinates wave propagation through a defined gap junction network among non-neuronal retinal cells, excluding photoreceptors. Wave intensity scales with ommatidial size, triggering stronger myosin II-driven apical contraction at interommatidial boundaries in larger ommatidia. This size-dependent mechanism compensates for early boundary irregularities, ensu

SUBMITTER: Choi BJ 

PROVIDER: S-EPMC12916253 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature