Add-on PD-1 inhibitor with Peg-IFNα therapy favors functional cure of chronic hepatitis B patients.

ABSTRACT:

Background and objectives

The treatment options for hepatitis B surface antigen (HBsAg) clearance are limited for patients who have failed pegylated interferon-α (Peg-IFNα) therapy. Given preclinical evidence that PD-1 blockade boosts antiviral immunity, this study aims to evaluate the efficacy and safety of PD-1 inhibitors in chronic hepatitis B (CHB) patients who have failed interferon therapy.

Methods

This non-randomized controlled trial was conducted in CHB patients who failed to achieve HBsAg clearance after 48 weeks of Peg-IFNα therapy. Including two groups: (i) a PD-1 inhibitor plus Peg-IFNα group receiving sintilimab 1 mg/kg/12 weeks plus Peg-IFNα 180 μg/week (n = 33) or (ii) a Peg-IFNα group continuing Peg-IFNα therapy (n = 31). The primary endpoint wa

SUBMITTER: Li Y 

PROVIDER: S-EPMC12916265 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature