Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders.

ABSTRACT: We aimed to develop and validate a risk estimation model for developing bipolar-spectrum disorders (BSD) in psychiatrically hospitalized adolescents based on clinical characteristics, including putatively prodromal symptoms. Adolescent inpatients (ages = 12-18 years) with non-psychotic/non-BSD diagnoses were recruited for the Adolescent Mood Disorder and Psychosis Study (AMDPS), a longitudinal, prospective 5-year follow-up cohort. We assessed prevalence and severity of syndromal/subsyndromal psychopathology at baseline using the validated Bipolar Prodrome Symptom Interview and Scale-Prospective. We carried out machine learning analyses (Lasso-Cox regression analyses, LCR) to create a calculator to estimate the risk of developing BSD based on baseline demographic/comorbidity/illness/treatme

SUBMITTER: Salazar de Pablo G 

PROVIDER: S-EPMC12916283 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature