Gene-specific selective sweeps are pervasive across human gut microbiomes.

ABSTRACT: The human gut microbiome is composed of a highly diverse consortia of species that are continually evolving within and across hosts^1,2. The ability to identify adaptations common to many human gut microbiomes would show not only shared selection pressures across hosts but also key drivers of functional differentiation of the microbiome that may affect community structure and host traits. However, the extent to which adaptations have spread across human gut microbiomes is relatively unknown. Here we develop a new selection scan statistic named the integrated linkage disequilibrium score (iLDS) that can detect sweeps of adaptive alleles spreading across host microbiomes by migration and horizontal gene transfer. Specifically, iLDS leverages signals of hitchhiking of deleterious va

SUBMITTER: Wolff R 

PROVIDER: S-EPMC12916291 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature