Mapping the path to recovery: the intersection of cortical thickness reductions and serotonin transporter expression in anorexia nervosa.

ABSTRACT: Severe reductions in the brain's cortical gray matter thickness (CT) have repeatedly been reported in anorexia nervosa (AN). The underlying mechanisms of these drastic changes remain unclear. Associations with potential underlying neurochemical and metabolic features have not been evaluated. In this study, we investigated whether CT alterations, across the cortical surface, in AN (n = 114) compared to healthy controls (HC; n = 114 age-matched, range 12-29 years old) might be associated with the spatial distribution of neurotransmitter receptors, transporters and/or metabolic glucose uptake (i.e., "chemoarchitecture", based on data from PET binding studies in healthy individuals, as implemented by neuromaps). First, the correlation between CT alterations in AN and chemoarchitecture was eval

SUBMITTER: Tarchi L 

PROVIDER: S-EPMC12916299 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature